Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential.

نویسندگان

  • Lucy Vandeputte-Rutten
  • Martine P Bos
  • Jan Tommassen
  • Piet Gros
چکیده

The neisserial surface protein A (NspA) from Neisseria meningitidis is a promising vaccine candidate because it is highly conserved among meningococcal strains and induces bactericidal antibodies. NspA is a homolog of the Opa proteins, which mediate adhesion to host cells. Here, we present the crystal structure of NspA, determined to 2.55-A resolution. NspA forms an eight-stranded antiparallel beta-barrel. The four loops at the extracellular side of the NspA molecule form a long cleft, which contains mainly hydrophobic residues and harbors a detergent molecule, suggesting that the protein might function in the binding of hydrophobic ligands, such as lipids. In addition, the structure provides a starting point for structure-based vaccine design.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 278 27  شماره 

صفحات  -

تاریخ انتشار 2003